The Nusano HALEU Knowledge Center is a practical resource for understanding high-assay low-enriched uranium, the advanced nuclear fuel expected to power many next-generation reactors. Here, readers can learn what HALEU is, how it differs from conventional low-enriched uranium, why supply remains a critical challenge, and how new approaches to enrichment, fuel form, and domestic production could help accelerate advanced reactor deployment. Designed for reactor developers, policymakers, investors, journalists, and technical researchers, this knowledge center connects the fundamentals of uranium enrichment with the market, technology, and supply-chain issues shaping the future of clean, reliable nuclear energy.